These pregnancy specific biological substances have immense cell therapy applications in regenerative medicine to treat non-healing ulcers at the backdrop of leprosy, burn and leprosy wounds, and nonhealing ulcers due to trauma or diabetes. The placenta with the amniotic membrane, amniotic fluid, the placental cord and the fetal umbilical cord blood can be considered as pregnancy specific biological substances as they appear during the time of pregnancy to support the process of pregnancy and fetal development. It also helps in the fetal circulation and removal of fetal waste materials. Keywords: Amniotic membrane Amniotic fluid Placenta Regenerative medicine.ĭuring the time of pregnancy, the placenta plays an important role in providing a barrier that allows the selective exchange of molecules and cells between the mother and the fetus without compromising the integrity of the fetal development. Amniotic fluid like amniotic membrane is also a biological substance having superior cell therapy properties and can be often used in regenerative medicine for clinical applications due to its high content of amniocytes, amniotic fluidderived stem cells, and growth factors.
Freshly collected amniotic membrane is another application of cell therapy using pregnancy specific biological substances. The main advantage of this method is that as it is freshly collected, and not artificially processed or parched, its cellular components, growth factors, cytokines all remain intact and together they act as a superior biological dressing for the healing of wounds and ulcers including as a biological scaffold. However, since 1999, Bhattacharya et al., freshly collected amniotic membranes have been also successfully used for treating burn and other non-healing ulcer patients. Clinical application of the dry and dehydrated human amniotic membrane (dHAM), chemically and thermally processed amniotic membranes has been used for closure and protection of wounds against infection for some time.
Like cord blood, the placenta is also thrown away as a biological hazard in many countries without understanding its true potentialities. The amniotic membranes of the placenta have been successfully used in burn and chronic non-healing ulcer dressings. It also helps in the removal of the fetal waste materials. The placenta is an important blood-placental barrier organ that plays an important part during the time of pregnancy by allowing the selective exchange of molecules and gases. This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Application of Freshly Collected Amniotic Membrane and Amniotic Fluid in Arthritis and Wound Healing. *Corresponding authors: Niranjan Bhattacharya, Head, Department of Regenerative Medicine and Translational Science, Calcutta School of Tropical Medicine, Director General of Cord Blood Bank, Calcutta School of Tropical Medicine, India, Tel: +91 9830038158, E-mail: Sengupta, Department of Regenerative Medicine and Translational Science, Calcutta School of Tropical Medicine, Email: May 29, 2018Ĭitation: Bhattacharya N, Sengupta P, Bhattacharya A. Subhas Mukherjee Chair Professor, Director General, Cord Blood Bank, Calcutta School of Tropical Medicine, IndiaĢResearch Associate, Department of Regenerative Medicine and Translational Science, Calcutta School of Tropical Medicine, India Niranjan Bhattacharya 1*, Priyodarshi Sengupta 2* and Akash Bhattacharya 2ġHead of the Department of Regenerative Medicine and Translational Science, Dr. Application of Freshly Collected Amniotic Membrane and Amniotic Fluid in Arthritis and Wound Healing